The game is a prequel to the Land of the Dead film, taking place during the initial outbreak of the zombie epidemic. Players take on the role of a farmer named Jack, who, one day, finds his farm besieged by the undead. After finding the other nearby farms desolate, he makes his way to the city, hoping to find help, but instead finding the city in ruins, overrun by the undead. Jack later learns about the existence of a safe-haven located within the city, and makes it his priority to reach it.
Land of the Dead: Road to Fiddler's Green utilizes traditional first-person shooter gameplay. Players can use a variety of either melee weapons or firearms to fight through the zombie hordes. Some weapons are capable of dismembering the zombies, whilst other weapons are not. The zombies' jaws, heads, arms, forearms, and legs can be shot or chopped off by the player. This can very effectively save the player so as to make an escape. The zombies themselves appear in many varieties (regular, ones armed with a melee weapon, crawlers, puking ones, screamers that summon other zombies, and poisonous, exploding ones) and each takes a different amount of hits to kill, which varies upon the difficulty setting of the game. The player cannot become a zombie, but it is stated that people who die for any reason become zombies, like in the movie. The multiplayer component of the game consists of many online game types. These consist of deathmatch, team deathmatch, and "Capture the Flag" modes. There is also an "Invasion" (co-op survival) mode, in which players are trapped in a small map where they must survive for a chosen amount of time. In this mode, the weapons and ammunition regenerate in the same spots each time, allowing the players to dodge the burden of ammunition shortages. Players can pick up melee weapons from recently killed melee weapon wielding zombies as well. In some variants of Invasion maps, players who die or are bitten by zombies become zombies themselves, and try to kill their former teammates.